Cefradine Impurity 12

Cefradine Impurity 12 - Names and Identifiers

Name	sodium (R)-α-[(3-methoxy-1-methyl-3-oxo-1-propenyl)amino]cyclohexa-1,4-diene-1-acetate
Synonyms	26774-89-0 Cefradine Impurity 12 NSWNOOKQXWSJGP-YEUQMBKVSA-M D-Dihidro phenylglycine Sodium Dane Salt sodium (R)-α-[(3-methoxy-1-methyl-3-oxo-1-propenyl)amino]cyclohexa-1,4-diene-1-acetate sodium (2R)-2-cyclohexa-1,4-dien-1-yl-2-[[(E)-4-methoxy-4-oxobut-2-en-2-yl]amino]acetate sodium (2R)-cyclohexa-1,4-dien-1-yl{[(1Z)-3-methoxy-1-methyl-3-oxoprop-1-en-1-yl]amino}ethanoate (r)-(+)-alpha-[(3-methoxy-1-methyl-3-oxo-1-propenyl)amino]-1,4-cyclohexadiene-1-aceticacidsodiumsalt (R)-(+)-Alpha-[(3-Methoxy-1-Methyl-3-Oxo-1-Propenyl)Amino]-1,4-Cyclohexadiene-1-Acetic Acid Sodium Salt
CAS	26774-89-0
EINECS	248-000-1
InChI	InChI=1/C13H17NO4.Na/c1-9(8-11(15)18-2)14-12(13(16)17)10-6-4-3-5-7-10;/h3-4,7-8,12,14H,5-6H2,1-2H3,(H,16,17);/q;+1/p-1/b9-8-;/t12-;/m1./s1

Cefradine Impurity 12 - Physico-chemical Properties

Molecular Formula	C13H18NNaO4
Molar Mass	275.28
Melting Point	240°C (dec.)(lit.)
Specific Rotation(α)	83 º (c=1, H2O)
Storage Condition	Room Temprature
Physical and Chemical Properties	Appearance: white or off-white crystalline powder
Use	Intermediate cefradine.

Cefradine Impurity 12 - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing.
WGK Germany	3

Cefradine Impurity 12 - Introduction

sodium (R)-α-[(amino)] cyclohexa-1,4-diene-1-acetate is a chemical compound with the formula C17H21NO5Na.

Nature:
sodium (R)-α-[(amino)] cyclohexa-1,4-diene-1-acetate is a white crystalline powder that is soluble in water. Its pH range is between 7-9.

Use:
sodium (R)-α-[(amino)] cyclohexa-1,4-diene-1-acetate are widely used as pharmaceutical intermediates and synthetic raw materials. It is commonly used in the manufacture of drugs such as phenadine, inosine, and pramipexole. It is also used in research areas.

Method:
The preparation of sodium (R)-α-[(amino)] cyclohexa-1,4-diene-1-acetate involves a multi-step organic reaction. First, through a series of organic synthesis steps, the synthesis of phenylglycine. Phenylglycine is then condensed with an appropriate aldehyde and reduced to give dihydrophenylglycine. Finally, the dihydrophenylglycine is reacted with an appropriate acid to form the corresponding dihydrophenylglycine hydrochloride, which is then reacted with sodium hydroxide to give sodium (R)-α-[amino]cyclohexa-1,4-diene-1-acetate.

Safety Information:
sodium (R)-α-[(amino)] cyclohexa-1,4-diene-1-acetate is relatively safe under normal conditions of use. However, like all chemical substances, appropriate practices and safe operating procedures must be followed. Inhalation of the powder or direct contact with the skin and eyes should be avoided. Wear appropriate personal protective equipment, including lab gloves and goggles, when using the compound. In the case of accidental contact, rinse immediately with plenty of water and seek medical help.

Last Update：2024-04-09 21:01:54